Some are speculating that drug dealers might be somehow involved in people losing their powers after a record amount of users have ended up in Venture City Hospital over the last week. This makes sense provided that people who used to have powers would want to get them back, even if temporarily. It is also believed that the effects of the super drug tend to wear off faster than they used to, causing users to buy more to maintain the high they used to receive.
Others still cling to the idea that PAS is behind the loss but this does seem unlikely since they are not known for having resources for something this massive. However, after the events at the festival in November of last year, they appear to have acquired more resources than they previously had.